【文章标题】：Four Weeks of a Vegan Diet Alter Signs of Inflammation and Aging 【文章标题】：四周纯素饮食改变炎症与衰老标志物
【文章正文】： Four Weeks of a Vegan Diet Alter Signs of Inflammation and Aging Nutrition study involving 48 healthy adults / Researchers analyze more than 800,000 genetic loci / Evidence of changes in inflammatory processes, metabolism, and biological aging 四周纯素饮食改变炎症与衰老标志物 48名健康成年人参与的营养学研究/科研人员分析了超80万个基因位点/发现炎症进程、新陈代谢与生物衰老的变化证据
Just four weeks of dietary changes can already be reflected in epigenetic changes. This is shown by a study conducted by theUniversity Center for Naturopathy at the Medical Center – University of Freiburg and the University of California, San Diego, involving 48 healthy adults. The research team led by PD Dr. Maximilian Storz, Lukas Karbacher, M.Sc., and Prof. Dr. Jerome Mertens (University of California, San Diego) investigated how a vegan diet or a diet particularly high in meat affects epigenetic marks on the surface of DNA. In the process, they found evidence of changes in biological signaling pathways associated with, among other things, inflammatory responses, cell growth, and biological aging. The results were published on August 3, 2026, in the journal MedComm. 仅四周的饮食改变就能在表观遗传层面产生可检测的变化。这项由弗莱堡大学医学中心自然疗法研究中心与加州大学圣地亚哥分校联合开展的研究，通过对48名健康成年人的观察证实了这一点。由Maximilian Storz博士、Lukas Karbacher硕士和Jerome Mertens教授（加州大学圣地亚哥分校）领导的研究团队，探究了纯素饮食与高肉饮食对DNA表面表观遗传标记的影响。研究过程中，他们发现了与炎症反应、细胞生长和生物衰老相关的生物信号通路变化证据。该成果于2026年8月3日发表在《MedComm》期刊。
“Our findings show that a dietary change can trigger measurable changes at the epigenetic level within just a few weeks,” says Storz, a specialist at the University Center for Naturopathy at the Department of Medicine II at the Medical Center – University of Freiburg and one of the study’s lead authors. “Now, larger and longer-term studies must show whether these changes are permanent and how they can be integrated into existing treatment regimens.” “我们的研究证明，饮食改变能在短短数周内引发表观遗传层面的可测量变化，“该研究主要作者之一、弗莱堡大学医学中心第二医学部自然疗法研究中心专家Storz表示，“接下来需要通过更大规模、更长期的观察，来验证这些变化是否具有持续性，以及如何整合到现有治疗方案中。”
More Than 800,000 Genetic Locations Analyzed 超80万个基因位点分析
After a one-week period of standardized nutrition, the participants were randomly assigned to two groups: 24 followed a vegan diet for four weeks, while 24 followed a diet particularly high in meat. Energy intake was to remain as constant as possible. Blood samples were collected before and after the dietary change. In total, the research team analyzed approximately 800,000 DNA sites for so-called methylation—chemical marks that can influence how active certain genes are. 在经历一周标准化饮食后，受试者被随机分为两组：24人进行四周纯素饮食，另24人采用高肉饮食。两组均保持尽可能恒定的能量摄入。研究人员在饮食干预前后分别采集血样，总计分析了约80万个DNA位点的甲基化情况——这种化学标记能影响特定基因的活跃程度。
After four weeks, changes were observed in several biological signaling pathways in the vegan group. Among other things, these changes affected processes that regulate cell growth, metabolism, and cell repair. For example, the activity of the mTOR signaling pathway was reduced; excessive activation of this pathway can promote uncontrolled cell growth. At the same time, signaling pathways associated with insulin action, cell repair, stress responses, and healthy aging were more strongly activated. 四周后，纯素饮食组多个生物信号通路出现变化。这些改变影响了细胞生长调控、新陈代谢和细胞修复等过程。例如mTOR信号通路活性降低——该通路过度激活可能引发细胞异常增殖；而与胰岛素作用、细胞修复、应激反应及健康衰老相关的信号通路则被显著激活。
The researchers also found differences in the immune system: In the vegan group, there were fewer neutrophils—a type of white blood cell that can promote inflammatory responses—and more CD4+ T cells, which play an important role in regulating the immune response. Overall, this pattern suggests a less pro-inflammatory immune response. 研究还发现免疫系统差异：纯素饮食组的中性粒细胞（一种促进炎症反应的白细胞）减少，而调控免疫应答的关键细胞CD4+ T细胞增多。整体呈现促炎性较低的免疫反应特征。
Original title of the study:A vegan diet epigenetically modulates inflammatory pathways and biological aging: Genome-wide DNA methylation analysis of a one-month isocaloric vegan versus meat-rich dietary intervention 研究原题：《纯素饮食通过表观遗传调控炎症通路与生物衰老：基于全基因组DNA甲基化的等热量纯素vs高肉饮食一个月干预分析》
DOI: 10.1002/mco2.70899 DOI编号：10.1002/mco2.70899
Link to the study:https://doi.org/10.1002/mco2.70899 论文链接：https://doi.org/10.1002/mco2.70899
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