【文章标题】：Weekly Dose of Optimism #208
【每周乐观主义 第208期】
【文章正文】：
Hi friends 👋,
朋友们好👋，
Happy Friday and welcome back to our 208th Weekly Dose of Optimism.
周五快乐，欢迎回到第208期《每周乐观主义》。
While there was a ton of good news this week, the videos of the floods in Nepal and Tibet are some of the most heartbreaking I’ve ever seen. We’re going to cover the good stuff, but if you’d like to donate to the relief efforts, I’m giving to
尽管本周好消息不断，但尼泊尔和西藏的洪灾视频仍是我见过最揪心的画面。我们会报道积极的内容，但若您想参与救灾捐赠，我推荐
DirectRelief’s Nepal Flood Relief 2026
DirectRelief尼泊尔洪灾2026救援项目
, where 100% of donations support Nepal response activities.
该机构将100%的善款用于尼泊尔救灾行动。
Now, August rules: you should be outside as much as possible while you can, so we will just quickly tell you to
八月法则：趁阳光正好多出门活动，所以我们只快速提醒您
check out “Matthew’s” Field Notes from China
阅读《马修的中国田野笔记》
, and then…
然后…
Let’s get to it.
进入正题。
Today’s Not Boring is brought to you by…
本期内容由…赞助
Create
Create品牌
Dan and Sienna rolled out what looks like the most delicious creatine ever made, the
丹和西耶娜推出了堪称史上最美味肌酸产品的
Lemonade Collection
柠檬风味系列
To celebrate, they agreed to give not boring readers 50% off through the weekend.
为庆祝上市，他们为本栏目读者提供周末五折优惠
Go get your Lemonade Creatine + Electrolytes and code notboring50 at checkout
结账时使用notboring50优惠码购买柠檬肌酸电解质饮品
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FDA Approves Targeted Therapy for Metastatic Pancreatic Cancer
FDA批准转移性胰腺癌靶向疗法
Xavier Martinez for WSJ
《华尔街日报》Xavier Martinez报道
Pancreatic cancer has long been one of the deadliest and hardest to treat forms of the disease thanks to a mutation that sticks the RAS protein on and causes runaway cell growth.
由于RAS蛋白突变导致细胞无限增殖，胰腺癌长期是最致命且难治的癌症之一。
In terrible news for cancer and great news for people, the FDA has approved a drug, Revolution Medicines’ Rasonque, that targets the mutation and helped subjects in a late-stage study live for more than 13 months instead of around 6.7 months for those who receive chemotherapy alone.
对癌症是噩耗、对人类是好消息的是：FDA批准了Revolution Medicines公司的Rasonque药物。该药针对该突变，使晚期研究受试者生存期从单纯化疗的6.7个月延长至13个月以上。
The drug does have side effects, and 13 months isn’t forever, both issues personified by “Former Nebraska Sen. Ben Sasse, who went public in the spring with what he described as a significant reduction in his tumors while in a clinical trial of the drug, appeared on television with his face covered in red blotches.” Sasse lived longer than expected, but he still expects to pass away, as discussed in his incredible conversation with Leopold’s wedding officiant Ross Douthat, titled “
该药确有副作用，且13个月并非永久——前内布拉斯加州参议员本·萨斯就是例证。他在春季公开表示参与临床试验后肿瘤显著缩小，但电视露面时满脸红斑。正如他在与利奥波德婚礼主持罗斯·杜塔特的深刻对谈《
How Ben Sasse is Living Now That He is Dying
濒死之本·萨斯如何活着
”.”
》中所述，他虽比预期活得久，仍准备迎接死亡。
Still, this is a massive win, one that drew a standing ovation at a cancer conference last spring when Revolution announced the results.
但这仍是重大胜利——去年春季Revolution公布结果时，癌症会议全场起立鼓掌。
As one patient, former Disney exec Jay Williams, told WSJ, “What it does is buy you time, and that’s one thing you don’t always have with pancreatic cancer.”
前迪士尼高管杰伊·威廉姆斯告诉《华尔街日报》：“它为你争取时间，而这正是胰腺癌患者最缺的。”
And speaking of time, good on the FDA for approving this so quickly. Per the Agency, “The FDA granted Rasonque Breakthrough Therapy and Orphan Drug designations. Rasonque received Priority Review for this indication. The application was also reviewed under the Commissioner’s National Priority Voucher pilot program, which is intended to help accelerate the review of therapies that address national public health priorities.” As a result, it was approved about 6.5 months faster than the standard PDUFA timeline, which means means it went through in roughly half the usual already-accelerated window for a priority oncology drug.
谈及时效，FDA快速审批值得称赞。据其声明：“Rasonque获突破性疗法和孤儿药认定，享受优先审评，并通过局长国家优先凭证试点计划加速。“因此比标准PDUFA时间表提前6.5个月获批，仅用优先肿瘤药物常规加速流程的一半时间。
Patients, oncologists, all of us, and regulators are saying the same thing: get fucked, cancer.
患者、肿瘤医生、我们所有人乃至监管机构都在说：去死吧，癌症。
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Airbound Announces $37M Raise and Drops Manifesto
Airbound获3700万美元融资并发布宣言
Naman Pushp for Airbound
Airbound创始人Naman Pushp撰文
Last year, I invested in a company called Airbound founded by a young guy from India who taught himself physics and engineering on YouTube during COVID and used that knowledge to build better drones.
去年我投资了Airbound公司，其创始人是个印度小伙——疫情期间通过YouTube自学物理工程，并借此造出更好的无人机。
After we got introduced but before we met, I didn’t really think I’d invest - drones are a fairly crowded space and Zipline is awesome. Then I met Naman, and decided to invest immediately.
初闻其名未见其人时，我本无投资意向——无人机赛道拥挤且Zipline很优秀。但见到Naman后我当即决定投资。
Over the past couple of months, I’ve had the chance to work with him on his
过去几个月我有幸与他合作
Manifesto for Airbound
《Airbound宣言》
, in which he did a great job laying out the future where all movement is in the air that got me so excited in our first conversation.
他精彩描绘了”万物空中移动”的未来图景——正是我们初次交谈时最打动我的部分。
He published it this week, along with the news that he raised $37M from Greenoaks, Lachy Groom, and others.
本周他发布了宣言，同时宣布从Greenoaks、Lachy Groom等机构融资3700万美元。
Read it
阅读宣言
- and stay tuned for more.
- 敬请期待后续。
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Radiant and Antares Selected for US Army Janus Program
Radiant与Antares入选美军Janus计划
U.S. Army Communication and Outreach Office
美国陆军传播办公室
We love to see friends get contracts from the US Army to make a lot of nuclear reactors and hopefully save a lot of lives in the process, so we were very happy to see the Army choose
我们乐见朋友获得美军合同建造核反应堆并挽救生命，因此很高兴陆军选择
Radiant Nuclear
Radiant Nuclear
, who we wrote about in 2024, and Antares Nuclear, whose co-founder Julia DeWahl was my
（2024年我们报道过其事迹）与Antares Nuclear（联合创始人Julia DeWahl曾与我共同主持
Age of Miracles
《奇迹时代》
co-host, sign deals as two of five companies selected for the $2.2B Janus program.
节目）签约成为22亿美元Janus计划五家入选企业之二。
Radiant is getting $750M to make 15 Kaleidos microreactors, and while Antares didn’t reveal specifics on this contract, they tweeted that they “
Radiant获7.5亿美元生产15台Kaleidos微型反应堆，Antares虽未透露细节，但发推表示”
now have a contract value on the order of $1B that is growing rapidly.”
现有合同价值约10亿美元且快速增长”。
While the business side is awesome, the most important piece is what this might mean for warfighters. As Doug said in the deep dive, “
商业成就固然耀眼，但最关键的是对士兵的意义。正如道格在深度报道中所言：”
Over 55% of US soldier casualties in the two Iraqi conflicts are from ambushed convoys
伊拉克两场战争中超55%美军伤亡源于车队伏击
. And convoys move ammo, water, and fuel. So if you could put a reactor in one
而车队运输弹药、水和燃料。若能在一处部署反应堆…”